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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

• Ketoconazole, itraconazole (used to manage fungal infection)
• Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
• Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
• Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

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C. Preventing Pregnancy and Breastfeeding:

Cialis (tadalafil) is used to treat erectile dysfunction and pulmonary arterial hypertension. It is also used to treat kidney disease by increasing blood flow to the penis during sexual stimulation. However, Cialis is typically taken during sexual activity and not considered a treatable interaction.

Cialis is taken orally and can cause side effects in some individuals. These effects are usually mild and become less if you are taking higher doses or combining it with medications used for treating blood pressure disorders.

D. Managing Erectile Dysfunction

Cialis is used to treat erectile dysfunction (ED) and pulmonary arterial hypertension. It is also used to treat renal disease by increasing blood flow to the penis during sexual stimulation.

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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

• Ketoconazole, itraconazole (used to manage fungal infection)
• Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
• Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
• Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

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Avoid consuming grapefruit or grapefruit juice while taking Cialis, as it may interact with tadalafil, increasing its effectiveness.

C.

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness. Here are the key drug-food Interactions:

1. : Tadalafil can enhance the levels of tadalafil in your blood by impairing its metabolism. This increases theSuppressorfunction of the enzyme cGMP-specific phosphodiesterase 5 (PDE5). Avoid consuming grapefruit or grapefruit juice while using Cialis.
2. : Though not a direct interaction, combining Cialis with Cialis might worsening side effects like headaches or increase the amount of heart rate in sensitive individuals.

References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

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Cameroonian researchers Alps Biotechnology plc presented an interesting comparison of tadalafil 20mg and tadalafil 30mg (Additional Indication).https://www.nldc.nih.gov/posure/posure_assistance

6. Eli Lilly And tadalafil PCT: a comparison of efficacy and tolerability in patients withosteoporosis(osteoporosis) and [Accessed on November 08th, 2023]https://www. …

Mick Ficar, MD, and David S Watson, M. D. Tadalafil is an effective and well tolerated treatment for in patients with chronic- osteoporosis. NatureRLineal.https://www.npr.up.quebec.org.in/product/CCC5679064/

7. Electronic Medicines Compendium (EMC) [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.in/emc/files/pil.8637.pdf

8.

9. Electronic Medicines Compendium (EMC) [Revised in November 2009] [Accessed on November 08th, 2023]

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Chilean researcherschedelicMedicine Research plc presented an interesting comparison of tadalafil and sildenafil citrate (EMC) and sildenafil citrate’s efficacy and safety in men with pulmonary arterial hypertension (PAH) and compared their efficacy and safety in women with PAH and in healthy volunteers.

10. Merck & Co. P. A. - Clinical Product Description.

ThisCialis 20mg tablet is a treatment for male erectile dysfunction.

Before you begin taking Tadalafil generic, its important to carefully read the Patient Information Leaflet. Make sure to review it each time you get a refill.

Take Tadalafil dosage orally, either with or without food, as directed by your healthcare provider. Tadalafil dosage should not exceed more than once a day. Swallow the tablet whole. Do not split it or crush unless advised.

Your daily dosage will depend on your medical condition, how you respond to medications, and any other medications you currently take. Before you take ED treatment pills, ensure that you inform your healthcare service provider of any prescription drugs, over-the-counter medicines, and any other supplements you take.

If you are also using finasteride alongside Tadalafil to treat any symptoms of benign prostatic hyperplasia (BPH), discuss the duration of treatment and dosage you will need with your healthcare provider.

For erectile dysfunction (ED), tadalafil citrate may be prescribed in two ways:

• You may take it as needed, usually at least 30 minutes before sexual activity, with its effects potentially lasting up to 36 hours.
• Your doctor may recommend taking generic Cialis regularly, once a day.

Follow your doctors instructions carefully based on your specific needs and condition.

If you are using tadalafil citrate medication for ED dysfunction and BPH, take it daily as directed by your doctor. To ensure you do not forget, take it at the same time each day.

Keep your healthcare practitioner informed if your medical condition does not improve or worsens during treatment.

irlwinds do not like it when the temperature increases near the first recorded rise or decrease of the2.Tadalafil(Cialis) 2mg/5mgTadalafil 10mgYou may feel lightheaded if you experience prolonged andquistariness of the erect penis during sexual activity. This rare side effect has been reported as early as 6olicited messages and may deter some patients from taking it.

If you are also using tadalafil for BPH medication and BPHudden has not been reported, check with your doctor before taking tadalafil for BPHudden. It is not recommended for use in women or children.

Can you buy Cialis online in the U. S.?

No, you cannot buy Cialis online in the U. S. As in the U. S., you must purchase Cialis online from eDrugstore.com, which is a leading online prescription drug service. To learn more, visit our.

What is Tadalafil generic use?

Tadalafil generic use is primarily recognized as a treatment for erectile dysfunction (ED) and BPH. Its primary goal is to improve erectile function but can also be a potential side effect of generic Cialis for ED. As with any medication, there may be other applications for Tadalafil generic use.

• Tadalafil is also used for treatment of pulmonary arterial hypertension (PAH), who may have high blood pressure in the lungs, and for treatment of benign prostatic hyperplasia (BPH) in men.
• Generic Cialis (tadalafil) is also approved for treatment of BPH in women.
• In the United States, tadalafil generic Cialis (Cialis) is sold under the brand name Tadalafil and is also available as a generic drug as well as as a generic Tadalafil brand drug.

How should Tadalafil be stored?

You should store this medication in a cool dry place, out of the reach of children and away from moisture. Make sure that the packaging tightly sealed is kept underredibly cool conditions, like the temperature lower or higher than 77°F.

Tadalafil dosage for ED:

Generally, there is no specific amount to start and stop tadalafil use. The usual starting dose is 10mg three times a day, taken as needed. The maximum recommended dosing frequency is once daily.

Depending on your medical condition, you may be prescribed lower doses. Your doctor will tell you how many tadalafil tablets to take and how often to take them.

If you are using generic Cialis for ED medication, you may be advised to take it daily. The same principle is used by the doctor to determine the ideal dose for you.